Understanding how human antibodies can protect against tuberculosis
Characteristics and protective efficacy of human antibodies against M. tuberculosis
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-10721412
This study is looking at how certain antibodies in our bodies can help protect against tuberculosis (TB) and aims to find out how a vaccine called BCG can improve these antibody responses, which could lead to better vaccines and treatments for people with TB.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-10721412 on ClinicalTrials.gov |
What this research studies
This research investigates the role of human antibodies in providing protection against tuberculosis (TB), a serious infectious disease caused by Mycobacterium tuberculosis. The study aims to identify specific antibody responses that can be induced by vaccination, particularly focusing on the Bacillus Calmette-Guerin (BCG) vaccine, which has been used for nearly a century but offers limited protection. By characterizing the binding properties and functions of these antibodies, the research seeks to enhance our understanding of how they contribute to immunity against TB. Patients may benefit from insights that could lead to the development of more effective vaccines and therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been vaccinated with the BCG vaccine or those at risk of tuberculosis infection.
Not a fit: Patients who are not at risk for tuberculosis or those who have already developed active TB may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for tuberculosis, potentially reducing its incidence and mortality.
How similar studies have performed: Other research has shown promise in understanding antibody responses in infectious diseases, suggesting that this approach could yield valuable insights into TB immunity.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ACHKAR, JACQUELINE MICHELE — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: ACHKAR, JACQUELINE MICHELE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.