Understanding how human antibodies can fight multiple enteroviruses
Human Antibody Cross-Reactivity in Non-Polio Enteroviruses
This study is looking at how our immune system responds to different enteroviruses, which can lead to serious illnesses, to find out if certain antibodies can protect us against multiple strains, and it's for healthy adults who want to help improve future vaccines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11035113 on NIH RePORTER |
What this research studies
This research investigates the human immune response to various enteroviruses, which can cause serious illnesses like meningitis and acute flaccid myelitis. The team aims to identify the characteristics of antibodies that can provide protection against multiple strains of these viruses, rather than developing separate vaccines for each one. By studying blood samples from healthy adults, they will analyze how well these antibodies can cross-react with different enteroviruses. This knowledge could lead to the design of new vaccines that harness these cross-reactive antibodies for broader protection.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals of all ages, particularly those who may be at risk for enterovirus-related illnesses.
Not a fit: Patients with existing enterovirus infections or those who have already developed immunity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of vaccines that protect against a wide range of enterovirus infections, reducing the incidence of severe diseases.
How similar studies have performed: Previous research has shown promise in using monoclonal antibodies to treat enterovirus infections, indicating that this approach could be effective.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Vogt, Matthew R — Univ of North Carolina Chapel Hill
- Study coordinator: Vogt, Matthew R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.