Understanding how HTLV-1 virus spreads and assembles
Official title: Imaging of HTLV-1 by cryo-CLEM
Funded at University of Minnesota · NIH-10827963 · Data updated 2026-11-12
This study is looking at how the HTLV-1 virus spreads and causes health issues, with the goal of finding better ways to treat people affected by it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $193,750 |
| NIH project number | 5R21DE032878-02 |
| Project ID | NIH-10827963 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals infected with HTLV-1, particularly those experiencing symptoms related to adult T-cell leukemia or other associated conditions.
✕Less likely to help
Patients who are not infected with HTLV-1 or do not exhibit related health issues may not benefit from this research.
What this research studies
This research investigates the Human T-cell leukemia virus (HTLV-1), which affects millions globally and is linked to serious health conditions like adult T-cell leukemia and other inflammatory diseases. The study focuses on the virus's unique ability to spread through direct cell-to-cell contact, known as the virological synapse, and aims to uncover the mechanisms behind its assembly and transmission. By using advanced imaging techniques, researchers hope to gain insights into how the virus replicates and spreads, which could lead to better understanding and treatment options for those infected. Patients may benefit from the findings that could improve therapeutic strategies against HTLV-1-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and prevention strategies for patients affected by HTLV-1 and its associated diseases.
How similar studies have gone: Previous research has shown promise in understanding virus transmission through cell interactions, but this specific approach to studying HTLV-1 is relatively novel.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Mansky, Louis M. — University of Minnesota
- Study coordinator: Mansky, Louis M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.