Understanding how HSV-1 infection affects ribosome function and protein interactions
Official title: Investigating VICE domain functions tied to altered ribosome localization and translational flux during HSV-1 infection
Funded at Princeton University · NIH-11162005 · Data updated 2026-11-12
This study is looking at how the herpes simplex virus type-1 changes the way our cells work, especially how it affects the cell's nucleus and the production of proteins, which could help us understand more about the virus and improve treatments for people with HSV-1.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $32,974 |
| NIH project number | 1F31AI191634-01 |
| Project ID | NIH-11162005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with HSV-1 or those at risk of HSV-1 infection.
✕Less likely to help
Patients who do not have HSV-1 infection or are not at risk may not benefit from this research.
What this research studies
This research investigates how the herpes simplex virus type-1 (HSV-1) alters cellular processes, particularly focusing on the remodeling of the nucleus and the recruitment of proteins involved in ribosome biogenesis. By using advanced mass spectrometry techniques, the study aims to identify the interactions between viral and cellular proteins during infection. This could help clarify the role of Virus Induced Chaperone Enriched (VICE) domains in the infection process and their impact on protein synthesis. Patients may benefit from insights gained about HSV-1 and its effects on cellular functions.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of HSV-1 infection mechanisms, potentially informing new therapeutic strategies.
How similar studies have gone: Previous research has shown promising results in understanding viral interactions with cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Metzger, Peter — Princeton University
- Study coordinator: Metzger, Peter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.