Understanding how HSV-1 infection affects ribosome function and protein interactions
Investigating VICE domain functions tied to altered ribosome localization and translational flux during HSV-1 infection
['FUNDING_FELLOWSHIP'] · PRINCETON UNIVERSITY · NIH-11162005
This study is looking at how the herpes simplex virus type-1 changes the way our cells work, especially how it affects the cell's nucleus and the production of proteins, which could help us understand more about the virus and improve treatments for people with HSV-1.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PRINCETON UNIVERSITY (nih funded) |
| Locations | 1 site (Princeton, UNITED STATES) |
| Trial ID | NIH-11162005 on ClinicalTrials.gov |
What this research studies
This research investigates how the herpes simplex virus type-1 (HSV-1) alters cellular processes, particularly focusing on the remodeling of the nucleus and the recruitment of proteins involved in ribosome biogenesis. By using advanced mass spectrometry techniques, the study aims to identify the interactions between viral and cellular proteins during infection. This could help clarify the role of Virus Induced Chaperone Enriched (VICE) domains in the infection process and their impact on protein synthesis. Patients may benefit from insights gained about HSV-1 and its effects on cellular functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with HSV-1 or those at risk of HSV-1 infection.
Not a fit: Patients who do not have HSV-1 infection or are not at risk may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of HSV-1 infection mechanisms, potentially informing new therapeutic strategies.
How similar studies have performed: Previous research has shown promising results in understanding viral interactions with cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Princeton, UNITED STATES
- PRINCETON UNIVERSITY — Princeton, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: METZGER, PETER — PRINCETON UNIVERSITY
- Study coordinator: METZGER, PETER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.