Understanding how HPV16 affects host gene activity
Official title: Mechanisms and consequences of human papillomavirus 16 E2 regulation of host gene transcription
Funded at Virginia Commonwealth University · NIH-11030804 · Data updated 2026-11-12
This study is looking at how a specific protein from the HPV16 virus affects the way our cells read their genes, which could help us find new ways to treat cancers linked to HPV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | February 8, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $188,241 |
| NIH project number | 5R21AI178143-02 |
| Project ID | NIH-11030804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with HPV16 infections or those at risk for HPV-related cancers, such as cervical or anogenital cancers.
✕Less likely to help
Patients who do not have HPV infections or are not at risk for HPV-related cancers may not benefit from this research.
What this research studies
This research investigates the role of the E2 protein from human papillomavirus type 16 (HPV16) in regulating the transcription of host genes. By studying how E2 interacts with both viral and host DNA, the research aims to uncover mechanisms that allow HPV16 to replicate and persist in human cells. The approach includes using advanced techniques like RNA sequencing to analyze gene expression changes in cells expressing E2 compared to control cells. This understanding could lead to new strategies for targeting HPV-related cancers.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic approaches for treating HPV-related cancers.
How similar studies have gone: Previous research has shown that understanding viral mechanisms can lead to successful interventions in viral-related cancers, indicating potential for success in this area.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Morgan, Iain — Virginia Commonwealth University
- Study coordinator: Morgan, Iain
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.