Understanding how HPV-specific T cells affect treatment responses in head and neck cancer
Mechanistic connection between HPV-specific TCRs and therapeutic responses to ICI in HPV+ HNSCC
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11056170
This study is looking at how certain immune cells that fight HPV might affect how well treatments work for people with HPV-related head and neck cancer, hoping to find ways to help more patients respond better to their treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11056170 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between HPV-specific T cell receptors and how they influence the effectiveness of immune checkpoint inhibitors in treating head and neck squamous cell carcinoma (HNSCC) associated with HPV infection. By analyzing human samples from clinical trials and using mouse models, the study aims to uncover the mechanisms that determine why some patients respond well to treatment while others do not. The focus is on the immune responses to different HPV antigens, particularly the roles of T cells that target these antigens. This could lead to improved treatment strategies for patients with HPV+ HNSCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with HPV-positive head and neck squamous cell carcinoma.
Not a fit: Patients with HPV-negative head and neck squamous cell carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy treatments for patients with HPV+ head and neck cancer.
How similar studies have performed: Previous studies have shown promising results in using immune checkpoint inhibitors for HPV+ HNSCC, indicating that this research builds on established findings.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, JING HONG — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: WANG, JING HONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.