Understanding how HPV infections can lead to cancer
Cis-acting Elements in the Regulation of Papillomavirus Gene Expression
This study is looking at a protein called PRMT1 to see how it helps the HPV virus stick around in the body, which can lead to cancer, and they're hoping that by blocking this protein, they can find new ways to treat or prevent HPV-related cancers.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10744230 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, PRMT1, in the persistence of human papillomavirus (HPV) infections, which are linked to various cancers. By using advanced single-cell genomics techniques, the study aims to uncover how PRMT1 influences the splicing of viral genes, potentially leading to new treatment strategies. The researchers are exploring whether inhibiting PRMT1 can disrupt the viral lifecycle and reduce the risk of cancer associated with persistent HPV infections. This work could pave the way for developing new anti-cancer drugs targeting HPV-related malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with persistent HPV infections, particularly those at risk for developing cervical or other HPV-related cancers.
Not a fit: Patients who do not have HPV infections or those with resolved infections are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent HPV-related cancers.
How similar studies have performed: Other research has shown promise in targeting similar molecular pathways for cancer treatment, indicating potential for success in this approach.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Van Doorslaer, Koenraad — University of Arizona
- Study coordinator: Van Doorslaer, Koenraad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.