Understanding how HPV DNA integration contributes to cervical cancer development
Pathogenic role of human papillomavirus (HPV) DNA Integration and clonal expansion in cervical tumorigenesis
This study is looking at how high-risk HPV DNA mixes with our own DNA and how that might lead to cervical cancer, using advanced techniques to better understand the changes that happen in cells affected by HPV.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10922766 on NIH RePORTER |
What this research studies
This research investigates the role of high-risk Human Papillomavirus (hrHPV) DNA integration into the human genome and its impact on cervical cancer. The study employs advanced techniques like hybridization capture and next-generation sequencing to detect and map the junctions where HPV DNA integrates with human DNA. By analyzing clinical samples and a cell culture model, the research aims to characterize the structure of integrated viral DNA and the resulting changes in gene expression associated with cervical dysplasia and carcinoma. This comprehensive approach seeks to uncover the mechanisms behind HPV-related tumorigenesis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cervical dysplasia or cervical cancer, particularly those with high-risk HPV infections.
Not a fit: Patients without HPV-related cervical conditions or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potentially new treatments for cervical cancer linked to HPV.
How similar studies have performed: Previous research has shown promising results in understanding HPV integration and its role in cancer, indicating that this approach has potential for significant insights.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Van Arsdale, Anne — Albert Einstein College of Medicine
- Study coordinator: Van Arsdale, Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.