Understanding how HPV causes head and neck cancer
Dissecting NF-kB pathway in HPV-associated head and neck cancer
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10992680
This study is looking at how the HPV virus might lead to certain throat cancers and how a specific signaling pathway in our cells could help us find out which patients with HPV are more likely to do well with gentler treatments, making their experience easier and less harsh.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10992680 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which the human papillomavirus (HPV) contributes to head and neck squamous cell carcinoma (HNSCC). It focuses on the NF-kB signaling pathway, which may play a crucial role in the cancer's development and response to treatment. By analyzing data from multiple patient cohorts, the study aims to identify biomarkers that can predict which HPV+ patients are likely to benefit from less aggressive treatment options. This could help reduce the side effects associated with current therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with HPV-associated head and neck squamous cell carcinoma.
Not a fit: Patients with head and neck cancer not associated with HPV or those with other types of cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans for HPV+ head and neck cancer patients, potentially reducing treatment-related side effects.
How similar studies have performed: Previous research has shown promising results in understanding the role of the NF-kB pathway in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YARBROUGH, WENDELL G — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: YARBROUGH, WENDELL G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Induction, cancer microenvironment