Understanding how HPV and HIV affect cervical cancer in women
Official title: Project 3-- Determining biological and viral factors associated with clinical progression of cervical dysplasia in HIV-infected women
Funded at Indiana University Indianapolis · NIH-10897816 · Data updated 2026-11-12
This study is looking at how certain types of HPV and HIV work together to affect the risk of cervical cancer in women, especially in countries with fewer resources, and aims to find helpful signs in blood and cervical samples that could improve how we screen for and prevent this cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 7, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $143,843 |
| NIH project number | 5U54CA254518-05 |
| Project ID | NIH-10897816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who are HIV-positive and have been diagnosed with high-risk HPV infections.
✕Less likely to help
Patients who are not infected with HIV or high-risk HPV may not benefit from this research.
What this research studies
This research investigates the relationship between high-risk human papillomaviruses (HR HPVs) and HIV in driving the progression of cervical cancer in women, particularly in low and middle-income countries. The study aims to identify specific gene expression changes in cervical samples and blood that occur due to HR HPV infections and their interaction with HIV. By analyzing these biological markers, the research seeks to develop functional biomarkers that can help predict the risk of cervical cancer in affected women. This approach may lead to better screening and prevention strategies for cervical cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and prevention of cervical cancer in women infected with HPV and HIV.
How similar studies have gone: Other research has shown promising results in identifying biomarkers for cancer progression in HPV-infected populations, suggesting that this approach has potential for success.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Katzenellenbogen, Rachel Adria — Indiana University Indianapolis
- Study coordinator: Katzenellenbogen, Rachel Adria
Related research
Other NIH-funded projects on the same topics.
-
Topical ethanol gel for precise treatment of low-grade cervical dysplasia
A new topical gel using ethanol is being tested to treat low-grade cervical dysplasia in women, especially where access to regular care is limited.
-
Thermal ablation vs LEEP for cervical precancer in women with HIV
A clinical trial will compare two treatments, thermal ablation and LEEP, for high-grade cervical lesions in women living with HIV or other immunosuppression.
-
Antibodies and vaginal bacteria in HPV-related cervical changes
This project looks at whether antibodies bind different vaginal bacteria in women with HPV or cervical cell changes to understand why some women develop more serious lesions.
-
Image-guided ethanol ablation for treating cervical dysplasia
A doctor-led study is exploring a low-cost, image-guided treatment using ethanol to target cervical dysplasia in women, aiming to make care more accessible in underserved communities.
-
Antibodies and vaginal bacteria in HPV and cervical cell changes
This research looks at how antibodies attach to vaginal bacteria in people with HPV or different levels of cervical cell changes to better understand why some infections clear and others progress.
-
Investigating how bacteria and antibodies interact during HPV infection and cervical dysplasia
This study is looking at how certain bacteria in the vagina might affect the immune system and the risk of cervical issues in women with high-risk HPV infections, helping us understand how these factors could influence HPV clearance and the chances of developing cervical cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.