Understanding how HPV and HIV affect cervical cancer in women
Project 3-- Determining biological and viral factors associated with clinical progression of cervical dysplasia in HIV-infected women
This study is looking at how certain types of HPV and HIV work together to affect the risk of cervical cancer in women, especially in countries with fewer resources, and aims to find helpful signs in blood and cervical samples that could improve how we screen for and prevent this cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10897816 on NIH RePORTER |
What this research studies
This research investigates the relationship between high-risk human papillomaviruses (HR HPVs) and HIV in driving the progression of cervical cancer in women, particularly in low and middle-income countries. The study aims to identify specific gene expression changes in cervical samples and blood that occur due to HR HPV infections and their interaction with HIV. By analyzing these biological markers, the research seeks to develop functional biomarkers that can help predict the risk of cervical cancer in affected women. This approach may lead to better screening and prevention strategies for cervical cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are HIV-positive and have been diagnosed with high-risk HPV infections.
Not a fit: Patients who are not infected with HIV or high-risk HPV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and prevention of cervical cancer in women infected with HPV and HIV.
How similar studies have performed: Other research has shown promising results in identifying biomarkers for cancer progression in HPV-infected populations, suggesting that this approach has potential for success.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Katzenellenbogen, Rachel Adria — Indiana University Indianapolis
- Study coordinator: Katzenellenbogen, Rachel Adria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.