Understanding how HPV affects respiratory disease and vaccine response
Official title: Cell-Cell Signaling Driving HPV-Induced Respiratory Disease and Vaccine Response
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11074859 · Data updated 2026-11-12
This study is looking at how certain cells and viruses affect the way people with recurrent respiratory papillomatosis (RRP) respond to a new HPV vaccine, with the goal of finding better ways to help those who aren't getting better with current treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $95,392 |
| NIH project number | 1U01CA298630-01 |
| Project ID | NIH-11074859 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with recurrent respiratory papillomatosis caused by HPV types 6 and 11.
✕Less likely to help
Patients who do not have recurrent respiratory papillomatosis or those with other unrelated respiratory conditions may not benefit from this research.
What this research studies
This research focuses on recurrent respiratory papillomatosis (RRP), a serious condition caused by HPV types 6 and 11, which currently has no approved treatments. The project aims to identify specific cellular and viral biomarkers that influence how patients respond to the HPV therapeutic vaccine PRGN-2012. By analyzing the tumor microenvironment and immune responses, the researchers hope to enhance the effectiveness of the vaccine for patients who do not currently respond to treatment. This patient-centric approach involves collaboration to gather and analyze data that could lead to improved outcomes for individuals suffering from RRP.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with recurrent respiratory papillomatosis, potentially improving their quality of life.
How similar studies have gone: Previous clinical trials have shown promising results with similar HPV vaccine approaches, indicating potential for success in this area.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Wells, Susanne I — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Wells, Susanne I
Related research
Other NIH-funded projects on the same topics.
-
Household air pollution and child DNA changes tied to later lung health
A study in Guatemalan children looks at how early exposure to smoky kitchen fuel changes DNA and could influence respiratory health as they grow.
-
Genetic testing and specialist care for rare causes of chronic lung, sinus, and ear infections
This project offers stepwise genetic testing and specialty referrals to find rare inherited causes of recurring lung, sinus, and ear infections in children and adults.
-
Quantitative imaging to find chronic lung disease in high-risk patients
A project will use advanced chest CT image analysis to detect chronic lung diseases early in veterans, aiming to help people who might otherwise go undiagnosed.
-
Understanding lung diseases by combining genetic data and big biobank information
A big research project will look at genes, health data, and other biological information from diverse people to better understand why COPD and asthma develop and vary across populations.
-
Early-life household air pollution and DNA changes linked to childhood respiratory health in Guatemalan kids
This study looks at how exposure to smoke from solid fuel at home in early life may affect DNA and respiratory health in Guatemalan children enrolled in the HAPIN trial.
-
Long-term endotypes of prematurity-related lung disease in former preemies
A long-term study looking at why some babies born very early develop lasting breathing problems and how their genes might explain these different paths.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.