Understanding how HPV affects respiratory disease and vaccine response
Cell-Cell Signaling Driving HPV-Induced Respiratory Disease and Vaccine Response
This study is looking at how certain cells and viruses affect the way people with recurrent respiratory papillomatosis (RRP) respond to a new HPV vaccine, with the goal of finding better ways to help those who aren't getting better with current treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11074859 on NIH RePORTER |
What this research studies
This research focuses on recurrent respiratory papillomatosis (RRP), a serious condition caused by HPV types 6 and 11, which currently has no approved treatments. The project aims to identify specific cellular and viral biomarkers that influence how patients respond to the HPV therapeutic vaccine PRGN-2012. By analyzing the tumor microenvironment and immune responses, the researchers hope to enhance the effectiveness of the vaccine for patients who do not currently respond to treatment. This patient-centric approach involves collaboration to gather and analyze data that could lead to improved outcomes for individuals suffering from RRP.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with recurrent respiratory papillomatosis caused by HPV types 6 and 11.
Not a fit: Patients who do not have recurrent respiratory papillomatosis or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with recurrent respiratory papillomatosis, potentially improving their quality of life.
How similar studies have performed: Previous clinical trials have shown promising results with similar HPV vaccine approaches, indicating potential for success in this area.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Wells, Susanne I — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Wells, Susanne I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.