Understanding how HPV affects cervical cancer treatment
Enlisting HPV integration events to illuminate drivers and target treatment in invasive cervical cancer
This study is looking at how certain changes caused by the HPV virus might affect the growth of invasive cervical cancer, with the hope of finding new ways to treat women who are dealing with advanced or recurring cases of this cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10861758 on NIH RePORTER |
What this research studies
This research investigates the role of HPV integration events in invasive cervical cancer (ICC) to identify genes and pathways that could be targeted for treatment. By analyzing data from large cancer databases, the researchers aim to uncover how these viral integrations influence cancer progression and resistance to current therapies. The study will utilize advanced genomic and epigenomic techniques to pinpoint specific alterations in cancer cells, which may lead to more effective treatment options for patients. Ultimately, the goal is to improve outcomes for women suffering from advanced or recurrent ICC.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with advanced or recurrent invasive cervical cancer, particularly those who have shown resistance to current chemotherapy treatments.
Not a fit: Patients with early-stage cervical cancer or those not infected with HPV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that significantly improve survival rates for women with invasive cervical cancer.
How similar studies have performed: Other research has shown promising results in targeting HPV-related pathways in cervical cancer, indicating that this approach could be effective.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Rader, Janet S. — Medical College of Wisconsin
- Study coordinator: Rader, Janet S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.