Understanding how house dust mites trigger airway hyperreactivity in asthma
Official title: Sensory neuronal mechanism for development of house dust mite induced airway hyperreactivity
Funded at University of South Florida · NIH-11049885 · Data updated 2026-11-12
This study is looking at how tiny house dust mites can make asthma worse in kids under 11 by affecting certain nerves in their airways, with the goal of finding better treatments that tackle the root of the problem instead of just easing the symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $387,116 |
| NIH project number | 1R01HL168051-01A1 |
| Project ID | NIH-11049885 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who suffer from asthma, particularly those with symptoms triggered by house dust mites.
✕Less likely to help
Patients with asthma not triggered by house dust mites or those over the age of 11 may not receive benefit from this research.
What this research studies
This research investigates the mechanisms by which house dust mites (HDM) contribute to airway hyperreactivity (AHR) in asthma patients, particularly in children under 11 years old. The study focuses on identifying specific sensory nerve populations that are activated by HDM and how these nerves lead to excessive airway responses. By understanding these neural mechanisms, the research aims to develop targeted therapies that can more effectively treat AHR, which is a major cause of asthma symptoms and exacerbations. Patients may benefit from new treatments that address the underlying causes of their asthma rather than just alleviating symptoms.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target the mechanisms of airway hyperreactivity in asthma, improving management and outcomes for patients.
How similar studies have gone: While there has been research on asthma and airway hyperreactivity, this specific focus on the sensory neuronal mechanisms triggered by house dust mites is relatively novel and has not been extensively tested.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Patil, Mayur Jayanta — University of South Florida
- Study coordinator: Patil, Mayur Jayanta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.