Understanding how host proteins affect alphavirus infections
Official title: Mechanisms of novel host factors in alphavirus infection
Funded at Albert Einstein College of Medicine · NIH-11096083 · Data updated 2026-11-12
This study is looking at how certain proteins in our bodies interact with alphaviruses, like the chikungunya virus, to help us understand how these viruses infect us and grow, which could lead to new treatments for people affected by these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $210,000 |
| NIH project number | 5R21AI182834-02 |
| Project ID | NIH-11096083 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been infected with alphaviruses or are at risk of such infections.
✕Less likely to help
Patients who are not affected by alphavirus infections or do not have a history of related viral diseases may not benefit from this research.
What this research studies
This research investigates the role of host proteins in the life cycle of alphaviruses, which include significant human pathogens like the chikungunya virus. By using innovative techniques such as biotinylation and mass spectrometry, the study aims to identify specific host proteins that interact with the virus during infection. This could lead to new insights into how the virus enters cells and replicates, ultimately informing the development of antiviral therapies. Patients may benefit from this research as it seeks to uncover potential targets for effective treatments against these viral infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies for alphavirus infections.
How similar studies have gone: Other research has shown promise in identifying host factors in viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Martin, Caroline K — Albert Einstein College of Medicine
- Study coordinator: Martin, Caroline K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.