Understanding how host factors influence the replication of herpes simplex virus
Official title: ROLES OF HOST FACTORS IN VIRAL REPLICATION COUPLED PROCESSES
Funded at Duquesne University · NIH-11015063 · Data updated 2026-11-12
This study is looking at how the herpes virus makes copies of its DNA and how it works with our body's cells, with the hope of finding new ways to treat herpes infections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duquesne University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | February 7, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $334,650 |
| NIH project number | 5R01AI158361-04 |
| Project ID | NIH-11015063 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with herpes simplex virus, particularly those experiencing recurrent outbreaks or antiviral resistance.
✕Less likely to help
Patients who do not have herpes simplex virus infections or those with other unrelated viral infections may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms by which herpes simplex virus (HSV) replicates its DNA and how it interacts with host cellular factors. By using advanced proteomic and genome-wide assays, the study aims to uncover how HSV-1 coordinates its DNA synthesis with the host's DNA repair and transcription processes. Patients may benefit from insights gained into potential new antiviral therapies that target these interactions, ultimately improving treatment options for herpes infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antiviral therapies for herpes simplex virus infections.
How similar studies have gone: Previous research has shown success in understanding viral replication mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duquesne University
Pittsburgh, United States Active
Researchers
- Principal investigator: Dembowski, Jill Ann — Duquesne University
- Study coordinator: Dembowski, Jill Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.