Understanding how host factors influence flavivirus infections
Official title: Host Regulation of Flavivirus Infection
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11166111 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells can influence the way viruses like dengue and Zika replicate, with a focus on a specific enzyme called NS3, to help find new ways to treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | June 6, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $530,385 |
| NIH project number | 1R01AI186249-01A1 |
| Project ID | NIH-11166111 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals at risk for or affected by flavivirus infections, such as dengue or Zika virus.
✕Less likely to help
Patients who are not at risk for flavivirus infections or those who have already been treated successfully may not receive benefit from this research.
What this research studies
This research investigates how certain host cell factors regulate the replication of flaviviruses, such as dengue and Zika viruses, which are transmitted by mosquitoes. The study focuses on the role of a specific enzyme, NS3, and how its activity is modified by acetylation, a biochemical process that can affect viral replication. By using advanced techniques like RNA interference and molecular studies, the research aims to uncover the mechanisms behind this regulation, potentially leading to new antiviral strategies. Patients may benefit from insights gained that could inform the development of targeted antiviral therapies.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral treatments for diseases caused by flaviviruses.
How similar studies have gone: Previous research has shown promising results in understanding viral interactions with host factors, suggesting that this approach could yield significant insights.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Gack, Michaela Ulrike — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Gack, Michaela Ulrike
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.