Understanding how hormones affect prostate cancer
New Insight of Androgen Signaling in Prostate Cancer Initiation and Progression
This research aims to better understand how male hormones drive prostate cancer growth and resistance to current treatments, which could help men with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10893627 on NIH RePORTER |
What this research studies
Prostate cancer is a common and serious disease in men, and current treatments often target the male hormone pathway. While initial treatments can be very effective, many patients eventually develop a form of cancer that resists these therapies. We want to uncover the specific ways that male hormones, like testosterone, continue to fuel prostate cancer even when treatments try to block them. By finding these hidden mechanisms, we hope to identify new ways to stop cancer growth and overcome treatment resistance.
Who could benefit from this research
Good fit: This foundational research is for men with prostate cancer, particularly those whose disease has progressed or become resistant to standard hormone treatments.
Not a fit: Patients without prostate cancer or those whose cancer is fully controlled by current therapies may not directly benefit from this specific research at this stage.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for prostate cancer, especially for patients whose cancer has become resistant to existing hormone therapies.
How similar studies have performed: Previous data from this team and others suggest that prostate cancer cells may still depend on hormone pathways even when treatments aim to block them, indicating a promising area for further investigation.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Sun, Zijie — Albert Einstein College of Medicine
- Study coordinator: Sun, Zijie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.