Understanding how hormones affect opioid relapse in new mothers

Hormonal Response to Infant Caregiving: A Novel Strategy to Break the Opioid Relapse Cycle during the Postpartum Period

NIH-funded research University of Arizona · NIH-10001201

This study is looking at how taking care of a baby affects hormones in new moms and how these changes might help them stay on track after struggling with opioid use, with the hope of finding better ways to support them during this important time.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Arizona NIH-funded
Lab location1 site (Tucson, United States)
Project IDNIH-10001201 on NIH RePORTER

What this research studies

This research investigates the hormonal changes that occur during infant caregiving and how these changes can help prevent opioid relapse in postpartum women. By examining hormones like cortisol, progesterone, and oxytocin, the study aims to develop new strategies to support mothers recovering from opioid use disorder. The approach includes innovative methodologies to assess hormonal responses over time and their relationship to caregiving behaviors. The ultimate goal is to create effective interventions that can reduce the risk of relapse during the vulnerable postpartum period.

Who could benefit from this research

Good fit: Ideal candidates for this research are postpartum women who have a history of opioid use disorder and are at risk of relapse.

Not a fit: Patients who are not postpartum or do not have a history of opioid use disorder may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide new therapeutic strategies to help mothers avoid relapse into opioid use, improving health outcomes for both mothers and their infants.

How similar studies have performed: While there is limited research specifically targeting hormonal interventions for postpartum opioid relapse, similar studies have shown promise in using hormonal approaches for substance use disorders.

Where this research is happening

Tucson, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.