Understanding how hormones affect immune cells in aging
Deciphering hormonal regulation of neutrophil biology
This project looks at how hormones influence important immune cells called neutrophils, and how these differences might impact health as people get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11112544 on NIH RePORTER |
What this research studies
This project explores why immune responses, especially those involving key cells called neutrophils, can be different between men and women as they age. We know that immune cells in males and females are distinct throughout life, but we don't fully understand why. This work aims to uncover how sex hormones and chromosomes play a role in these differences. By understanding these mechanisms, we hope to learn more about how the immune system functions differently in men and women, which could lead to better health strategies for everyone.
Who could benefit from this research
Good fit: This foundational work is relevant to all adults, particularly those interested in understanding sex-specific differences in immune health and aging.
Not a fit: Patients seeking immediate clinical interventions or direct treatment options would not directly benefit from this foundational biological research.
Why it matters
Potential benefit: If successful, this work could help us understand why men and women experience immune responses differently, potentially leading to new ways to support immune health as we age.
How similar studies have performed: While the specific mechanisms of hormonal regulation of neutrophil biology are still being deciphered, there is accumulating evidence supporting widespread sex-dimorphism in biological processes and immune responses.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Benayoun, Berenice Anath — University of Southern California
- Study coordinator: Benayoun, Berenice Anath
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.