Understanding How Hormones Affect Breast Cancer Cells
Hormone Receptor Regulation of RNA Polymerase III
This project explores how hormones control the growth of breast cancer cells, aiming to find new ways to stop cancer from growing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11121729 on NIH RePORTER |
What this research studies
Our bodies have special "steroid receptors" that respond to hormones like estrogen and androgen, which are important for normal body functions but also play a role in cancer. These hormones send signals that can change how genes work, influencing how cells grow and develop. While we know a lot about how hormones affect one major way genes are regulated, we've found a second important way they control cell growth. This work focuses on understanding this newly discovered pathway to better understand how breast cancer cells grow and spread.
Who could benefit from this research
Good fit: This foundational work is for patients interested in the basic biological mechanisms driving hormone-sensitive breast cancer, which could inform future clinical trials.
Not a fit: Patients whose cancers are not driven by hormone receptors or who are seeking immediate clinical intervention would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new drug targets and improved treatments for hormone-sensitive breast cancers by uncovering fundamental mechanisms of cell growth.
How similar studies have performed: This project explores a newly uncovered layer of hormone receptor activity, suggesting a novel approach to understanding cell growth and cancer.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Sartorius, Carol Ann — University of Colorado Denver
- Study coordinator: Sartorius, Carol Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.