Understanding how hormones affect blood sugar control in diabetes
Etiology of Impaired Counterregulation in Glucose Homeostasis: Exploring the Roles of Glucagon, Somatostatin, Cortisol, and Epinephrine through Mathematical Modeling of Oral Glucose Tolerance Tests
This study looks at how different hormones affect blood sugar levels in people with diabetes, aiming to understand why some people struggle to manage low blood sugar, which could lead to serious health issues, and hopes to find better ways to treat diabetes based on these insights.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11014453 on NIH RePORTER |
What this research studies
This research investigates the roles of various hormones, including glucagon, somatostatin, cortisol, and epinephrine, in regulating blood sugar levels, particularly in individuals with diabetes. By using mathematical modeling of oral glucose tolerance tests, the study aims to uncover the mechanisms behind impaired counterregulation of glucose, which can lead to dangerous conditions like hypoglycemia. The findings could help improve treatment strategies for diabetes by identifying how these hormones interact during glucose fluctuations.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with type 1 or late-stage type 2 diabetes who experience issues with blood sugar regulation.
Not a fit: Patients without diabetes or those who do not experience hypoglycemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for diabetes, reducing the risk of hypoglycemia and improving overall glucose control.
How similar studies have performed: Previous research has shown success in understanding hormonal interactions in glucose regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Subramanian, Vijaya — Johns Hopkins University
- Study coordinator: Subramanian, Vijaya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.