Understanding How Hormone Receptors Break Down
Characterizing a Common Degradation Pathway for Nuclear Hormone Receptors
This research aims to understand how certain hormone receptors, which play a role in common cancers like breast and prostate cancer, are naturally broken down in the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11174477 on NIH RePORTER |
What this research studies
Many common cancers, such as breast and prostate cancer, are driven by signals from special proteins called nuclear hormone receptors. Current medicines for these cancers often work by targeting these receptors. This project focuses on a newly discovered way these receptors are naturally broken down after they receive a hormone signal. By learning more about this process, we hope to find new ways to control these receptors and potentially develop more effective treatments.
Who could benefit from this research
Good fit: This foundational research is for future patients who may be diagnosed with cancers driven by nuclear hormone receptors, such as breast or prostate cancer.
Not a fit: Patients whose cancers are not driven by nuclear hormone receptors would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new and more effective drugs for hormone-driven cancers like breast and prostate cancer.
How similar studies have performed: While this specific degradation mechanism is a new discovery, existing successful cancer drugs already work by influencing the breakdown of these same hormone receptors.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Tsai, Jonathan Michael — Brigham and Women's Hospital
- Study coordinator: Tsai, Jonathan Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.