Understanding how hormone changes during puberty affect depression risk in girls
Defining the Neuropathophysiological Mechanisms Linking Ovarian Hormone Variability with Depression Risk in Peripubertal Girls
This study is looking at how changes in hormones during puberty might affect feelings and reactions to stress in teenage girls, with the goal of understanding why some may be more likely to experience depression, so we can better support those who need it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10898912 on NIH RePORTER |
What this research studies
This research investigates the relationship between ovarian hormone variability and the risk of depression in adolescent girls during puberty. It focuses on how changes in hormones like estradiol may influence emotional responses and cognitive control, particularly in relation to stress and rejection sensitivity. By employing various methods, including neurophysiological assessments, the study aims to uncover the mechanisms that contribute to increased vulnerability to depression during this critical developmental period. The findings could help identify at-risk individuals and inform prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescent girls aged 12 to 20 who are experiencing puberty.
Not a fit: Patients outside the age range of 12 to 20 or those who are not experiencing puberty may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of depression in adolescent girls.
How similar studies have performed: Previous research has indicated a link between hormonal changes and mental health outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Andersen, Elizabeth Helen — Univ of North Carolina Chapel Hill
- Study coordinator: Andersen, Elizabeth Helen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.