Understanding how hormonal changes affect therapy outcomes for OCD
2/2 Harnessing Hormonal Variation to Probe Neural Mechanisms and Optimize CBT Outcomes for OCD
This study is looking at how cognitive behavioral therapy (CBT) for obsessive compulsive disorder (OCD) works differently for women based on their hormone levels, especially estrogen, to help improve treatment outcomes and understand brain activity during therapy sessions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10890639 on NIH RePORTER |
What this research studies
This research investigates how cognitive behavioral therapy (CBT) for obsessive compulsive disorder (OCD) interacts with hormonal variations, particularly estrogen levels, to influence treatment outcomes. The study will examine the neural mechanisms involved in fear and anxiety responses during therapy sessions, focusing on differences between men and women. By analyzing brain activity and treatment responses in relation to menstrual cycle phases, the research aims to optimize therapy for women with OCD. Participants will undergo assessments before and after therapy to evaluate changes in symptoms and brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with OCD who are between 21 and 40 years old.
Not a fit: Patients who are not women or those who do not have a diagnosis of OCD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatment strategies for women with OCD.
How similar studies have performed: Previous research has shown promising results in understanding the impact of hormonal variations on mental health treatments, suggesting potential for success in this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Foa, Edna B — University of Pennsylvania
- Study coordinator: Foa, Edna B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.