Understanding how hormonal changes affect migraines and mood disorders in women and girls.
Official title: Characterization and Digital Phenotyping of Migraine and Affective Disorders during Hormonal Fluctuations across the Life Course
Funded at Brigham and Women's Hospital · NIH-11051994 · Data updated 2026-11-12
This study is looking at how migraines and mood changes are connected in women and girls during different times in their lives, like puberty and menopause, and it’s designed for those who experience both migraines and mood issues to help understand their symptoms better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $185,220 |
| NIH project number | 1K01MH136417-01A1 |
| Project ID | NIH-11051994 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women and girls of reproductive age who experience migraines and/or affective disorders.
✕Less likely to help
Patients who do not experience migraines or affective disorders may not benefit from this research.
What this research studies
This research investigates the relationship between migraines and affective disorders, particularly in women and girls, during hormonal fluctuations throughout their lives. By collecting detailed data on migraine occurrences and mental health symptoms, the study aims to identify unique patterns and characteristics of individuals who experience both conditions. The approach includes longitudinal assessments that track changes over time, especially during significant hormonal transitions such as puberty, postpartum, and menopause. Participants will use mobile technology to report their symptoms in real-time, providing valuable insights into how these disorders interact.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for women suffering from migraines and mood disorders.
How similar studies have gone: Previous research has shown promising results in understanding the links between hormonal changes and migraines, but this specific approach is relatively novel.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Crowe, Holly Michelle — Brigham and Women's Hospital
- Study coordinator: Crowe, Holly Michelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.