Understanding how HNF1A affects pancreatic beta-cell diversity in diabetes
Comprehensive characterization of HNF1A-driven beta-cell heterogeneity
This study is looking at how changes in a gene called HNF1A affect the cells in your pancreas that make insulin, which is important for managing blood sugar, and it aims to help us understand more about Type 2 diabetes and how we might improve treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10980162 on NIH RePORTER |
What this research studies
This research investigates the role of the HNF1A gene in creating diversity among pancreatic beta-cells, which are crucial for insulin production. By using advanced techniques like single-cell multiome analysis, the researchers aim to uncover how variations in HNF1A influence beta-cell function and contribute to conditions like Type 2 diabetes. The study will also involve creating stem cell models to manipulate HNF1A levels, allowing for a deeper understanding of its effects on beta-cell behavior and diabetes progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Type 2 diabetes or those with a family history of diabetes, particularly those with known HNF1A mutations.
Not a fit: Patients without diabetes or those whose diabetes is not linked to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for diabetes by targeting the mechanisms behind beta-cell diversity.
How similar studies have performed: Previous research has shown promising results in understanding beta-cell heterogeneity, but this specific approach focusing on HNF1A is relatively novel.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Li, Yan — Case Western Reserve University
- Study coordinator: Li, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.