Understanding how HMG Co-A Synthase 1 is broken down in cells
Official title: Mechanism and Significance of HMG Co-A Synthase 1 Degradation
Funded at Sloan-Kettering Inst Can Research · NIH-11085298 · Data updated 2026-11-12
This study looks at how a key enzyme that helps our cells grow and communicate breaks down, and it aims to find out how things like nutrients and growth signals affect this process, which could help us understand and improve treatments for cancer and other metabolism-related diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 7, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $330,130 |
| NIH project number | 5R01GM152667-02 |
| Project ID | NIH-11085298 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may have conditions related to metabolic dysregulation or cancer.
✕Less likely to help
Patients with conditions unrelated to the mevalonate pathway or those under 21 years old may not receive benefit from this research.
What this research studies
This research investigates the mechanisms behind the degradation of HMG Co-A Synthase 1, an important enzyme in the mevalonate pathway, which is crucial for cell signaling and membrane formation. The study focuses on how this enzyme's stability is influenced by various factors, including nutrient availability and cell growth signals. By examining the role of the ubiquitin proteasome system in regulating this enzyme, the research aims to uncover new insights into metabolic control in cells. Patients may benefit from understanding how these processes affect cancer and other diseases linked to metabolism.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cancer and metabolic disorders by targeting the regulation of key enzymes.
How similar studies have gone: Previous research has shown success in targeting metabolic pathways for cancer treatment, suggesting that this approach may also yield significant findings.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: An, Heeseon — Sloan-Kettering Inst Can Research
- Study coordinator: An, Heeseon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.