Understanding how HLA genetics affects kidney transplant success
Official title: HLA Immunogenetics and kidney allograft outcomes
Funded at University of Pennsylvania · NIH-10991029 · Data updated 2026-11-12
This study is looking at how certain genetic differences in proteins called HLA alloantigens can affect the success of kidney transplants, helping doctors understand how to match donors and recipients better for improved transplant outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | November 21, 2022 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $728,342 |
| NIH project number | 5R01AI173095-03 |
| Project ID | NIH-10991029 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals undergoing kidney transplantation who have specific HLA genetic profiles.
✕Less likely to help
Patients who are not candidates for kidney transplantation or those with incompatible HLA types may not benefit from this research.
What this research studies
This research investigates the role of HLA alloantigens in kidney transplantation, focusing on how genetic variations in these proteins can influence the success of kidney grafts. By analyzing the genetic makeup of both donors and recipients, the study aims to identify specific amino acid variations that may lead to immune responses against transplanted kidneys. The research will utilize advanced molecular typing techniques to gather comprehensive data on HLA mismatches and their correlation with transplant outcomes, particularly in diverse patient populations. This approach seeks to improve organ allocation strategies and enhance long-term graft survival.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney transplant outcomes and longer-lasting grafts for patients.
How similar studies have gone: Previous studies have shown promising results in understanding HLA mismatches and their impact on transplant outcomes, indicating that this research builds on established findings.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Kamoun, Malek — University of Pennsylvania
- Study coordinator: Kamoun, Malek
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.