Understanding how HLA genetics affects kidney transplant success
HLA Immunogenetics and kidney allograft outcomes
This study is looking at how certain genetic differences in proteins called HLA alloantigens can affect the success of kidney transplants, helping doctors understand how to match donors and recipients better for improved transplant outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10991029 on NIH RePORTER |
What this research studies
This research investigates the role of HLA alloantigens in kidney transplantation, focusing on how genetic variations in these proteins can influence the success of kidney grafts. By analyzing the genetic makeup of both donors and recipients, the study aims to identify specific amino acid variations that may lead to immune responses against transplanted kidneys. The research will utilize advanced molecular typing techniques to gather comprehensive data on HLA mismatches and their correlation with transplant outcomes, particularly in diverse patient populations. This approach seeks to improve organ allocation strategies and enhance long-term graft survival.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing kidney transplantation who have specific HLA genetic profiles.
Not a fit: Patients who are not candidates for kidney transplantation or those with incompatible HLA types may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney transplant outcomes and longer-lasting grafts for patients.
How similar studies have performed: Previous studies have shown promising results in understanding HLA mismatches and their impact on transplant outcomes, indicating that this research builds on established findings.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kamoun, Malek — University of Pennsylvania
- Study coordinator: Kamoun, Malek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.