Understanding how HLA-DQ affects organ transplant success
Official title: The immunogenicity and pathogenicity of HLA-DQ in solid organ transplantation
Funded at Northwestern University at Chicago · NIH-10909194 · Data updated 2026-11-12
This study is looking at how certain proteins called HLA-DQ can affect the success of organ transplants, especially how antibodies against them might cause the body to reject the new organ, with the goal of helping patients have better transplant outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 17, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $799,998 |
| NIH project number | 5R01AI170728-02 |
| Project ID | NIH-10909194 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing solid organ transplantation who may have mismatched HLA-DQ molecules.
✕Less likely to help
Patients who are not undergoing organ transplantation or those with fully matched HLA types may not benefit from this research.
What this research studies
This research investigates the role of HLA-DQ molecules in organ transplantation, particularly how antibodies against these molecules can lead to transplant rejection. The study aims to uncover the mechanisms behind the increased immunogenicity of HLA-DQ compared to other HLA molecules, such as HLA-DR and HLA-DP. By analyzing the immune response to these mismatches, the research seeks to identify which HLA-DQ mismatches are permissible and which are not, potentially improving transplant outcomes for patients. The approach involves a combination of immunological assays and evolutionary analysis to understand the differences in immune activation pathways.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for organ transplantation, reducing the risk of rejection and enhancing graft survival.
How similar studies have gone: Previous research has shown that understanding HLA mismatches can significantly impact transplant outcomes, suggesting that this approach has the potential for success.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Tambur, Anat R. — Northwestern University at Chicago
- Study coordinator: Tambur, Anat R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.