Understanding how HIV resists medicines
Mechanisms of HIV fitness and drug resistance inferred from high-resolution molecular dynamics and sequence co-variation models
This project aims to create new computer tools to predict how HIV changes over time to become resistant to current medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11136438 on NIH RePORTER |
What this research studies
This project focuses on understanding why HIV treatments sometimes stop working because the virus changes and becomes resistant. Researchers are building advanced computer models to forecast these changes, using detailed simulations of how HIV proteins behave. These computer predictions will be checked and improved with laboratory experiments on key HIV proteins, like integrase and capsid. The ultimate goal is to create a complete picture of how HIV mutations lead to drug resistance, helping us stay ahead of the virus.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals living with HIV who face challenges with drug resistance.
Not a fit: Patients whose HIV is well-controlled by current antiretroviral therapies may not see immediate direct benefit from this early-stage computational and laboratory work.
Why it matters
Potential benefit: If successful, this work could help scientists develop new strategies and drugs to overcome HIV drug resistance, making treatments more effective for longer.
How similar studies have performed: While computational modeling of viral evolution is an active field, this project aims to develop new, high-resolution tools and integrate them with experimental validation in a novel way.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Levy, Ronald — Temple Univ of the Commonwealth
- Study coordinator: Levy, Ronald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.