Understanding how HIV reservoirs grow and shrink in the body
Determinants of reservoir contraction and expansion in vivo, ex vivo, and in vitro
This study is looking at how HIV hides in certain immune cells in the body, even when people are on treatment, to help us understand why the virus can stick around and how it changes over time.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11091730 on NIH RePORTER |
What this research studies
This research investigates the dynamics of HIV reservoirs in the body, particularly focusing on infected CD4+ T cells that contribute to persistent viral presence even during antiviral therapy. By using advanced sequencing techniques, the study aims to measure the size and behavior of these reservoirs in individuals with HIV, including those treated during different stages of infection. The research will analyze how these reservoirs change over time and how they respond to treatment, providing insights into the mechanisms that allow HIV to persist despite therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV, particularly those who have undergone antiviral therapy and have varying responses to treatment.
Not a fit: Patients who are not living with HIV or those who have not received antiviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for eliminating HIV reservoirs, potentially resulting in better treatment outcomes for patients living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding HIV reservoirs, but this approach utilizing advanced sequencing techniques is relatively novel.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: O'doherty, Una T — Emory University
- Study coordinator: O'doherty, Una T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.