Understanding how HIV reservoirs grow and shrink in the body
Official title: Determinants of reservoir contraction and expansion in vivo, ex vivo, and in vitro
Funded at Emory University · NIH-11091730 · Data updated 2026-11-12
This study is looking at how HIV hides in certain immune cells in the body, even when people are on treatment, to help us understand why the virus can stick around and how it changes over time.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $701,363 |
| NIH project number | 4R37AI150556-06 |
| Project ID | NIH-11091730 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV, particularly those who have undergone antiviral therapy and have varying responses to treatment.
✕Less likely to help
Patients who are not living with HIV or those who have not received antiviral therapy may not benefit from this research.
What this research studies
This research investigates the dynamics of HIV reservoirs in the body, particularly focusing on infected CD4+ T cells that contribute to persistent viral presence even during antiviral therapy. By using advanced sequencing techniques, the study aims to measure the size and behavior of these reservoirs in individuals with HIV, including those treated during different stages of infection. The research will analyze how these reservoirs change over time and how they respond to treatment, providing insights into the mechanisms that allow HIV to persist despite therapy.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for eliminating HIV reservoirs, potentially resulting in better treatment outcomes for patients living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding HIV reservoirs, but this approach utilizing advanced sequencing techniques is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: O'doherty, Una T — Emory University
- Study coordinator: O'doherty, Una T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.