Understanding how HIV reservoirs form and persist in the body
Official title: Phylodynamic mechanisms of HIV reservoir seeding and maintenance
Funded at Fred Hutchinson Cancer Center · NIH-11008739 · Data updated 2026-11-12
This study is looking into how HIV hides in the body of people living with the virus, especially those taking medication, to help us understand why it stays there and how we might one day find a cure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 16, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $884,322 |
| NIH project number | 1R01AI186721-01 |
| Project ID | NIH-11008739 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV, particularly those who are on antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the formation and maintenance of HIV reservoirs in individuals living with HIV, particularly those on antiretroviral therapy. The team will utilize mathematical modeling to analyze existing and new data related to HIV viral loads, genetic sequences, and immune cell counts. By examining different stages of infection, both treated and untreated, they aim to identify the factors that contribute to the persistence of these reservoirs. This comprehensive approach will enhance our understanding of HIV biology and inform future strategies for achieving a cure.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for eliminating HIV reservoirs, potentially paving the way for a cure for HIV.
How similar studies have gone: Previous research has shown promise in understanding HIV reservoirs, but this specific approach using mathematical modeling is relatively novel.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Reeves, Daniel — Fred Hutchinson Cancer Center
- Study coordinator: Reeves, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.