Understanding how HIV replicates in immune cells called macrophages
Protein interactions regulating HIV replication in macrophages
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10886546
This study is looking at how HIV can multiply inside certain immune cells called macrophages, and it aims to find ways to stop this process by understanding how specific proteins work together, which could help create better treatments for people living with HIV/AIDS.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10886546 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that allow HIV to replicate within macrophages, which are immune cells that can harbor the virus. The study focuses on the interactions between specific proteins, including cyclin L2 and DYRK1A, to understand how they influence HIV infection. By exploring these interactions, the research aims to uncover potential targets for therapies that could disrupt HIV replication in these cells, which is crucial for developing effective treatments and potential cures for HIV/AIDS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, particularly those with a focus on understanding the role of macrophages in their infection.
Not a fit: Patients who are not infected with HIV or those whose HIV is already well-controlled with existing therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that effectively target HIV replication in macrophages, potentially improving outcomes for patients living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding HIV interactions with immune cells, but this specific approach focusing on cyclin L2 and DYRK1A in macrophages is relatively novel.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KYEI, GEORGE — WASHINGTON UNIVERSITY
- Study coordinator: KYEI, GEORGE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus