Understanding how HIV-related Kaposi Sarcoma progresses in patients receiving local treatment in Malawi and South Africa
Official title: Project 2: Clinical and molecular determinants of HIV-associated Kaposi Sarcoma progression under local standard-of-care therapy in Malawi and South Africa
Funded at Univ of North Carolina Chapel Hill · NIH-10891545 · Data updated 2026-11-12
This study is looking at how different factors affect the growth of Kaposi Sarcoma in people with HIV in Malawi and South Africa, with the goal of finding better treatments and ways to predict how the disease will progress.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 13, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $184,511 |
| NIH project number | 5U54CA254564-05 |
| Project ID | NIH-10891545 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who have been diagnosed with Kaposi Sarcoma and are receiving treatment in Malawi or South Africa.
✕Less likely to help
Patients who do not have HIV or who are not diagnosed with Kaposi Sarcoma may not benefit from this research.
What this research studies
This research investigates the clinical and molecular factors that influence the progression of Kaposi Sarcoma in patients living with HIV who are receiving standard care in Malawi and South Africa. The project aims to establish a collaborative research center that focuses on HIV-associated malignancies, leveraging expertise from institutions in the U.S. and Africa. By analyzing patient data and biological samples, the research seeks to identify new treatment options and prognostic biomarkers that could improve patient outcomes. The study builds on previous clinical trials and aims to provide insights into effective therapies for this common cancer in Sub-Saharan Africa.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better prognostic tools for patients with HIV-associated Kaposi Sarcoma.
How similar studies have gone: Previous research has shown success in identifying effective treatments for HIV-associated malignancies, making this approach promising.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Dittmer, Dirk P — Univ of North Carolina Chapel Hill
- Study coordinator: Dittmer, Dirk P
Related research
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Precision 3D Imaging to Monitor Kaposi Sarcoma (KS) with SkinScan3D
A new portable 3D imaging tool called SkinScan3D will help doctors measure KS skin lesions more accurately and quickly, especially in people living with HIV.
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Precision 3D Imaging to Track Kaposi Sarcoma (KS) with SkinScan3D
A new 3D imaging tool called SkinScan3D helps doctors monitor Kaposi sarcoma lesions more accurately and quickly, especially in settings with high KS burden like East Africa and in U.S. clinics with HIV patients.
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Kaposi Sarcoma care and research in Africa during ART era
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Kaposi Sarcoma in Africa: ART Era Research Network
A collaborative program in Africa and the United States will study Kaposi sarcoma in people living with HIV on ART to improve diagnosis, treatment, and prevention.
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Kaposi Sarcoma in Africa in the ART Era
This grant supports research to improve how Kaposi sarcoma is detected, treated, and understood in people living with HIV in Zambia and Tanzania during ART, with collaboration between African hospitals and a U.S. center.
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Faster detection and connection to care for people with HIV who develop Kaposi sarcoma in East Africa
This project aims to speed up finding people with HIV diagnosed with Kaposi sarcoma in East Africa and help them get linked to care more quickly.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.