Understanding how HIV proteins are processed for virus maturation
Official title: Dynamics and Evolution of HIV Gag and GagPol processing
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11118329 · Data updated 2026-11-12
This study is looking at how the HIV-1 virus grows and gets ready to infect cells by understanding how certain proteins work together, and the findings could help develop new treatments for people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | August 6, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $752,745 |
| NIH project number | 1R56AI179730-01A1 |
| Project ID | NIH-11118329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are seeking new treatment options.
✕Less likely to help
Patients who are not infected with HIV or those who have already achieved viral suppression may not benefit from this research.
What this research studies
This research investigates the maturation process of the HIV-1 virus, focusing on how the viral protease activates and processes specific proteins called Gag and GagPol. By using advanced molecular dynamics simulations, the study aims to uncover the timing and order of these proteolytic events, which are crucial for the virus's ability to mature and infect cells. The research will also explore the structural features of these proteins and how they interact with each other during this process. Patients may benefit from insights gained that could lead to new therapeutic strategies targeting HIV maturation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that inhibit HIV maturation, potentially improving outcomes for patients living with HIV.
How similar studies have gone: Previous research has shown promise in targeting viral maturation processes, suggesting that this approach could yield significant advancements in HIV treatment.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Munro, James B — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Munro, James B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.