Understanding how HIV progresses rapidly in infant macaques
Rapid disease progression and viral reservoir formation in SIV-infected infant macaques
This study looks at how quickly HIV can progress in baby macaques to help us understand why infants with HIV might get sick faster than adults, with the hope of finding better ways to help children living with the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11092927 on NIH RePORTER |
What this research studies
This research investigates the rapid progression of HIV infection in infant macaques, which serve as a model for understanding pediatric HIV. The study focuses on how immune dysfunction, characterized by low levels of specific antibodies and high viral loads, affects disease outcomes in young animals. By analyzing the immune responses and viral dynamics in these macaques, researchers aim to uncover the mechanisms that lead to faster disease progression in infants compared to adults. This could provide insights into potential interventions to improve outcomes for children infected with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and young children who are at risk of or are infected with HIV.
Not a fit: Patients who are adults or those without HIV infection are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment strategies for infants with HIV, potentially reducing mortality rates.
How similar studies have performed: Previous research using similar animal models has provided valuable insights into HIV progression, indicating that this approach has potential for success.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Sodora, Donald L — Seattle Children's Hospital
- Study coordinator: Sodora, Donald L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.