Understanding how HIV persists in the kidney
Mechanisms of HIV persistence in the kidney
This study is looking at how HIV can stick around in the kidneys even when people are on treatment, and it’s for anyone living with HIV who wants to help us understand how the virus behaves in this part of the body so we can find better ways to manage it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10889235 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which HIV remains in the kidney despite treatment. It focuses on how HIV infects kidney cells and the unique viral behavior in this organ. By analyzing urine samples from people living with HIV, the study aims to uncover the dynamics of HIV reactivation and replication in the kidney, which could inform future treatment strategies. The research employs advanced techniques to detect and analyze viral sequences from both urine and kidney cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, particularly those experiencing kidney-related complications.
Not a fit: Patients who are not living with HIV or those without kidney involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for eradicating HIV reservoirs in the kidney, potentially contributing to a cure for HIV.
How similar studies have performed: Previous research has shown promise in understanding HIV persistence in other tissues, but this specific focus on the kidney is relatively novel.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Blasi, Maria — Duke University
- Study coordinator: Blasi, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.