Understanding how HIV persists in the body despite treatment
Cellular Reservoirs of HIV
This study is looking at how certain blood cells in people with HIV can keep the virus alive even when they're on treatment, and it hopes to find new ways to help get rid of the virus for good, with the help of patients who can provide blood samples.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10684820 on NIH RePORTER |
What this research studies
This research investigates the role of CD4+ hematopoietic stem and progenitor cells (HSPCs) in the persistence of HIV in individuals undergoing antiretroviral therapy. It aims to understand how these cells can harbor the virus and contribute to ongoing viral replication, even when patients are on effective treatment. By analyzing the genetic makeup of HIV within these cells, the research seeks to identify potential pathways for eradicating the virus from the body. Patients may be involved in providing blood samples to help researchers study these cellular reservoirs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy.
Not a fit: Patients who are not infected with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for eliminating HIV from the body, potentially offering a cure for those living with the virus.
How similar studies have performed: Other research has shown promise in understanding HIV reservoirs, but this specific approach focusing on HSPCs is relatively novel.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Collins, Kathleen L. — University of Michigan at Ann Arbor
- Study coordinator: Collins, Kathleen L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.