Understanding how HIV persists in the body at the single-cell level
Defining Mechanisms of Viral Persistence in Situ at the Single-Cell Level
This study is looking into how HIV can hide in the body and stay inactive even when you're on treatment, so we can learn more about how to make better treatments that might help get rid of the virus for good.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10754521 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the persistence of HIV in the body, focusing on viral reservoirs that can remain dormant even during treatment. By examining individual cells, the study aims to identify how these reservoirs can reactivate and produce infectious virus after treatment is stopped. The approach involves analyzing both latent and active viral reservoirs in various tissues, which may provide insights into more effective treatment strategies. Patients may benefit from a deeper understanding of HIV persistence and potential new therapies aimed at eradicating the virus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have experienced viral suppression.
Not a fit: Patients who are not living with HIV or those who have never been on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for curing HIV by effectively targeting and eliminating viral reservoirs.
How similar studies have performed: Previous research has shown promise in understanding HIV reservoirs, but this approach of examining single-cell mechanisms is relatively novel.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Estes, Jacob D — Oregon Health & Science University
- Study coordinator: Estes, Jacob D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.