Understanding how HIV persists in brain cells
Viral dynamics of rebound and reservoir HIV species in IPSC-derived myeloid cells
This study is looking at how HIV can hide in certain brain cells, which might help the virus come back after treatment stops, and by understanding this better, we hope to find new ways to get rid of HIV for good.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10684814 on NIH RePORTER |
What this research studies
This research investigates how HIV hides in specific brain cells, particularly myeloid cells, which can harbor the virus and contribute to its rebound after treatment stops. By studying these cells, the research aims to uncover the mechanisms that allow HIV to remain in the central nervous system and evade eradication efforts. The approach includes analyzing viral dynamics and cellular interactions in a controlled laboratory setting, using advanced techniques to track HIV variants and their behavior in these cells. This knowledge could lead to new strategies for eliminating HIV from the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults living with HIV, particularly those who have experienced treatment interruptions or viral rebound.
Not a fit: Patients who are not living with HIV or those who have not been on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in curing HIV by targeting and eliminating the virus from brain reservoirs.
How similar studies have performed: Previous research has shown promise in understanding HIV reservoirs, but this specific approach focusing on myeloid cells in the CNS is relatively novel.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Akay Espinoza, Cagla — University of Pennsylvania
- Study coordinator: Akay Espinoza, Cagla
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.