Understanding how HIV persists and responds to treatment
High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Data Analytics & Modeling Core
This study is looking into why HIV can stick around in the body even when people are taking their medication, and it hopes to find new ways to help manage the virus better for those living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11080765 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the persistence of HIV in the body, even when patients are on antiretroviral therapy. It aims to generate detailed data on how HIV integrates into host cells and how it can reactivate. By using advanced data analytics and modeling, the project will analyze high-dimensional biological data to better understand the HIV reservoir. This knowledge could lead to improved therapeutic strategies for managing HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that eliminate the HIV reservoir, improving health outcomes for patients living with HIV.
How similar studies have performed: Previous research has shown promise in understanding HIV dynamics, but this approach aims to provide unprecedented detail and may lead to novel insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Li, Jonathan — Brigham and Women's Hospital
- Study coordinator: Li, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.