Understanding how HIV persists and contributes to treatment challenges
The heterogeneous HIV expressing reservoir: dynamics, persistence mechanisms, tissue distribution, and contribution to rebound
['FUNDING_P01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11080968
This study is looking at the different kinds of cells in the body that can keep HIV alive even when you're on treatment, to help find better ways to manage the virus and maybe even find a cure.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11080968 on ClinicalTrials.gov |
What this research studies
This research investigates the different types of HIV-expressing cells in the body that can reactivate and contribute to the virus's persistence despite treatment. By analyzing these cells, the study aims to identify their characteristics, including how they survive and their potential to cause a rebound of the virus after treatment interruption. The research employs advanced technologies to differentiate between various HIV RNA and protein expressions in these cells, which may lead to new insights into HIV treatment and potential cures.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who are undergoing antiretroviral therapy and may be experiencing treatment challenges.
Not a fit: Patients who are newly diagnosed with HIV or those who are not currently on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for eliminating HIV reservoirs and enhancing treatment outcomes for patients living with HIV.
How similar studies have performed: Previous research has shown promise in understanding HIV reservoirs, but this study aims to explore novel aspects that have not been fully characterized.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YUKL, STEVEN A — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: YUKL, STEVEN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, acute infection