Understanding how HIV particles are formed and structured
Official title: HIV particle morphology and biogenesis
Funded at University of Minnesota · NIH-10884358 · Data updated 2026-11-12
This study is looking at how the HIV-1 virus puts itself together, using special imaging techniques to understand the role of different proteins, which could help create better treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 7, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $715,974 |
| NIH project number | 5R01AI177264-02 |
| Project ID | NIH-10884358 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are seeking new treatment options.
✕Less likely to help
Patients who are not infected with HIV or those who are already on effective antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates the molecular interactions involved in the replication of HIV-1, focusing on how the virus particles are assembled and their morphology. By using advanced techniques like cryo-electron microscopy, the study aims to uncover the mechanisms behind the assembly of HIV particles and the role of various proteins in this process. The findings could lead to new targets for antiretroviral therapies and enhance our understanding of potential cures for HIV. Patients may benefit from this research as it could inform the development of more effective treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies and potential cures for HIV.
How similar studies have gone: Other research has shown success in understanding retroviral replication, making this approach promising for further advancements.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Mansky, Louis M. — University of Minnesota
- Study coordinator: Mansky, Louis M.
Related research
Other NIH-funded projects on the same topics.
-
Investigating biological markers related to human reproduction and development
This study is looking at how different factors in our bodies affect reproduction and the health of children and teens, and it's for anyone interested in understanding more about these important topics by analyzing samples like blood and urine without changing anything in their daily lives.
-
AI-powered liver cancer screening using ultrasound blood flow patterns
A new AI-based method analyzes liver blood flow signals to help detect liver cancer early in people with liver disease, especially in settings with limited resources.
-
Caregiver-led mobile tool to support healthy habits for kids treated for ALL
A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.
-
Understanding how survivorship care plans affect health outcomes for cancer survivors
A study will look at whether survivorship care plans help reduce deaths and improve health for adults who have survived cancer.
-
Understanding the experience of ovarian cancer after diagnosis to improve survivorship
This NIH grant funds a mixed-methods study to better understand physical and emotional challenges faced by ovarian cancer survivors and how supportive care can help them live better after diagnosis.
-
Minnesota Population Center: a hub for migration, family and community data science
A university research center helps researchers study population dynamics by sharing data, training researchers, and communicating findings to diverse audiences.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.