Understanding how HIV levels decrease in patients after starting treatment
Project 1: Analysis of 2nd phase decay in persons living with HIV
This study is looking at how quickly the HIV virus decreases in the blood of people starting treatment, helping us understand the different stages of this process and how the virus responds to the medicine.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11079496 on NIH RePORTER |
What this research studies
This research investigates the patterns of HIV decay in the blood of individuals living with HIV who are beginning antiretroviral therapy (ART). By measuring HIV-1 RNA levels over time, the study aims to identify two distinct phases of viral decay: a rapid initial decrease followed by a slower decline. The researchers will also examine changes in the frequency of infected cells to better understand the dynamics of the virus and its response to treatment. This work utilizes advanced digital droplet PCR technology to provide precise measurements of intact proviruses in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are starting antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who are not initiating ART may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for individuals living with HIV, enhancing their health outcomes.
How similar studies have performed: Previous research has successfully demonstrated similar approaches in understanding HIV dynamics, indicating a promising avenue for further exploration.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Siliciano, Robert F — Johns Hopkins University
- Study coordinator: Siliciano, Robert F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.