Understanding how HIV is transmitted through male foreskin
Development of an HIV infection model of human foreskin to obtain novel insights into virus transmission
This study is looking at how HIV spreads and affects male genital tissues by examining foreskin samples from circumcision in South Africa, to learn more about the immune cells involved and how other infections might make it easier for HIV to take hold.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | International Centre/genetc Engr/biotech NIH-funded |
| Lab location | 1 site (Cape Town, South Africa) |
| Project ID | NIH-10896081 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of HIV acquisition and transmission, particularly focusing on male genital tissues. By utilizing foreskin samples collected during medical male circumcision in South Africa, the study aims to identify the types of immune cells present and how they interact with HIV. The research will also explore how asymptomatic sexually transmitted infections may increase susceptibility to HIV infection. This approach combines molecular analysis with clinical insights to better understand early HIV infection events.
Who could benefit from this research
Good fit: Ideal candidates for this research are males undergoing medical male circumcision, particularly those with or without asymptomatic bacterial sexually transmitted infections.
Not a fit: Patients who are not male or those who do not have foreskin will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies against HIV transmission.
How similar studies have performed: While the specific approach of using foreskin tissues for this purpose is novel, similar studies have shown promise in understanding HIV transmission dynamics.
Where this research is happening
Cape Town, South Africa
- International Centre/genetc Engr/biotech — Cape Town, South Africa (Active)
Researchers
- Principal investigator: Chigorimbo-Tsikiwa, Nyaradzo Tsitsi — International Centre/genetc Engr/biotech
- Study coordinator: Chigorimbo-Tsikiwa, Nyaradzo Tsitsi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.