Understanding how HIV is transmitted in the body
Identification of the Initial Targets of Transmission
This study is looking at how HIV spreads in the body right after someone is exposed to it, aiming to find out which cells get infected first and how we can improve prevention methods like vaccines and treatments to help keep people safe from HIV.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10880232 on NIH RePORTER |
What this research studies
This research investigates the early stages of HIV transmission after mucosal exposure, focusing on identifying the first cells that become infected and how the virus spreads in the body. By using innovative techniques like beacon-guided necropsy, researchers aim to track the infection process in real-time, providing insights into the mechanisms of HIV transmission. The study also explores how to enhance the effectiveness of current prevention strategies, including vaccines and treatments. This work is crucial for developing better methods to prevent HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for HIV exposure, such as those with multiple sexual partners or those who engage in unprotected sex.
Not a fit: Patients who are already living with HIV or those who are not at risk for HIV exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV prevention strategies and vaccines, ultimately reducing the incidence of HIV infections.
How similar studies have performed: Other research in HIV prevention has shown promising results with similar innovative approaches, indicating potential for success in this area.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Hope, Thomas — Northwestern University at Chicago
- Study coordinator: Hope, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.