Understanding how HIV interacts with host cell proteins to affect virus release
HIV interactions with host cell proteins in particle release
This study is looking at how HIV-1 interacts with certain proteins in our cells, especially one called tetherin that helps stop the virus from spreading, and how another protein, Vpu, works to overcome this defense; it's for anyone interested in understanding more about how HIV works and finding new ways to fight it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Meharry Medical College NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10813740 on NIH RePORTER |
What this research studies
This research investigates the interaction between HIV-1 and host cell proteins, specifically focusing on a protein called tetherin that inhibits the release of the virus from infected cells. The study aims to explore how another protein, Vpu, neutralizes this inhibition through various mechanisms. By utilizing techniques such as live cell imaging and flow cytometry, researchers will analyze how a specific host protein, filamin A, influences the antiviral activity of tetherin and the release of HIV-1 particles. The goal is to gain insights into the molecular dynamics that could inform future therapeutic strategies against HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are interested in understanding the mechanisms of viral replication and transmission.
Not a fit: Patients who are not infected with HIV or those who are not engaged in HIV-related research may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing HIV transmission and improving treatment options for infected individuals.
How similar studies have performed: Previous research has shown promising results in understanding viral interactions with host cell proteins, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Meharry Medical College — Nashville, United States (Active)
Researchers
- Principal investigator: Dong, Xinhong — Meharry Medical College
- Study coordinator: Dong, Xinhong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.