Understanding how HIV interacts with brain cells
Role of Siglec-1 in HIV Interactions with Microglia and Astrocytes
This study is looking at how a molecule called Siglec-1 helps HIV affect brain cells, which could help us understand and find better ways to prevent or treat memory and thinking problems in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10834931 on NIH RePORTER |
What this research studies
This research investigates the role of a specific molecule, Siglec-1, in how HIV interacts with brain cells, particularly microglia and astrocytes. By using advanced techniques like cerebral organoids and iPSC-derived microglia, the study aims to uncover the mechanisms of HIV transmission within the central nervous system. The goal is to better understand the pathogenesis of HIV-associated neurocognitive disorders, which can affect individuals living with HIV even when they are on treatment. This research could lead to new insights into preventing or treating cognitive impairments related to HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may be experiencing cognitive impairments or are at risk for HIV-associated neurocognitive disorders.
Not a fit: Patients who are not living with HIV or who do not have any cognitive impairments related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating cognitive disorders in individuals living with HIV.
How similar studies have performed: Other research has shown promise in understanding HIV interactions with brain cells, but the specific role of Siglec-1 in this context is still being explored.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Spearman, Paul W. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Spearman, Paul W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.