Understanding how HIV integrates into the host genome and remains dormant
Official title: Host-Dependent Mechanisms that Guide the Longitudinal Dynamic of Sites of SIV Integration
Funded at Beth Israel Deaconess Medical Center · NIH-10950590 · Data updated 2026-11-12
This study is looking at how HIV hides in the body by sneaking into our genes and going into a quiet state, and it's for anyone interested in understanding how this virus can avoid the immune system, using samples from monkeys to learn more about what helps HIV stay hidden and how it affects our immune response.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $500,475 |
| NIH project number | 1DP2AI184811-01 |
| Project ID | NIH-10950590 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have achieved viral suppression.
✕Less likely to help
Patients who are not infected with HIV or those who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates the mechanisms by which HIV integrates into the host's genetic material and enters a dormant state, allowing it to evade the immune system. By studying samples from SIV-infected rhesus macaques, the research aims to identify the factors that influence where and how HIV integrates, as well as the effects of this integration on the host's immune response. The approach includes analyzing various host factors, such as metabolites and immune cell activity, to better understand their role in HIV latency and potential disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for eliminating latent HIV reservoirs, improving treatment outcomes for patients with HIV.
How similar studies have gone: Previous research has shown promise in understanding HIV latency and integration, but this specific approach using SIV-infected macaques is relatively novel.
Where this research is happening
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Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Boudries, Malika — Beth Israel Deaconess Medical Center
- Study coordinator: Boudries, Malika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.