Understanding how HIV infection persists despite treatment
Mathematical Modeling Core
This study is looking at why some HIV-1 cells stick around even when treatment is working well, and it hopes to find new ways to help people living with HIV by improving how we manage or even eliminate the virus.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11079490 on NIH RePORTER |
What this research studies
This research focuses on the challenges of eradicating HIV-1, particularly the long-lived latent reservoir of the virus that persists even with effective antiretroviral therapy (ART). By using mathematical modeling and precise assays, the research aims to analyze how infected cells behave over time and how they contribute to the reservoir. The goal is to gain insights into the factors that allow these cells to survive and potentially identify ways to eliminate them. Patients may benefit from improved treatment strategies that could lead to better management or eradication of HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently undergoing antiretroviral therapy.
Not a fit: Patients who are not infected with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective strategies for managing or potentially eradicating HIV infection.
How similar studies have performed: Previous research has shown promise in understanding HIV reservoirs, but this mathematical modeling approach is a novel application in this context.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Perelson, Alan S — Johns Hopkins University
- Study coordinator: Perelson, Alan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.